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Initially developed for type 2 diabetes, these agents are increasingly used for weight management, with landmark trials such as STEP and SELECT demonstrating double-digit weight loss and reduced risk of major cardiovascular events

Researchers are also evaluating retatrutide for type 2 diabetes (TRIUMPH-2), cardiovascular outcomes (TRIUMPH-3), and other conditions such as metabolic dysfunction-associated steatotic liver disease (MASLD)

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So the FDA moved them off Category 2 effective April 22

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